Genetic Signature of Skin Aging: A Pilot Study

Garoia et al., J Clin Exp Dermatol Res 2018, 9:6DOI: 10.4172/2155-9554.1000472

Genetic risk assessment is becoming an important component of clinical decision-making. Recent research has focused attention on the single nucleotide polymorphisms (SNPs) involved in the aging process. The aging process is a complex interaction of genetic and environmental factors. To evaluate the contribution of individual genetic variability to skin aging we combine the relatively small effects of individual genes in a multi locus genetic risk score (GRS). This study aims to evaluate whether the genetic risk score may be linked to the evolution of skin properties and provide personalized skin care and anti-age treatments.

A GRS was calculated using an additive model, based on the genotype analysis of 8 selected SNPs potentially associated with skin aging. One hundred patients were genotyped, tested for skin properties (elasticity, stratum corneum thickness, H2O content) and subjected to a questionnaire to evaluate sun exposure. ANCOVA analysis was performed to evaluate qualitative and quantitative explanatory variables. Once all the variables were taken in account, we found a significant correlation between GRS and elasticity and the thickness of the stratum corneum (SCT) suggesting that the combination of genetic signature, environmental and lifestyle information may provide a useful tool for personalized and more effective anti-aging therapies.



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